Background: The present study aimed to expound the association between the XK related 6 gene (XKR6)\nrs7819412 single nucleotide polymorphism (SNP) and serum lipid profiles and the risk of coronary artery disease\n(CAD) and ischemic stroke.\nMethods: The genetic makeup of the XKR6 rs7819412 SNP in 1783 unrelated participants (controls, 643; CAD, 588\nand ischemic stroke, 552) of Han Chinese was obtained by the Snapshot technology.\nResults: The genotypic frequencies of the SNP were disparate between CAD (GG, 81.0%; GA/AA, 19.0%) or ischemic\nstroke (GG, 81.2%; GA/AA, 18.8%) patients and healthy controls (GG, 85.7%, GA/AA, 14.3%; P < 0.05 vs. CAD or ischemic\nstroke; respectively). The A allele frequency was also diverse between CAD (10.1%) or ischemic stroke (10.0%) and\ncontrol groups (7.5%; P < 0.05 vs. CAD or ischemic stroke; respectively). The GA/AA genotypes and A allele were\nassociated with high risk of CAD and ischemic stroke (CAD: P = 0.026 for GA/AA vs. GG, P = 0.024 for A vs. G; Ischemic\nstroke: P = 0.029 for GA/AA vs. GG, P = 0.036 for A vs. G). The GA/AA genotypes were also associated with increased\nserum triglyceride (TG) concentration in CAD and total cholesterol (TC) concentration in ischemic stroke patients.\nConclusions: These data revealed that the XKR6 rs7819412 A allele was related to increased serum TG levels in CAD,\nTC levels in ischemic stroke patients and high risk of CAD and ischemic stroke.
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